Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug DevelopmentArticle Published on 2022-11-142022-11-15 Journal: Angewandte Chemie (International ed. in English) [Category] COVID19(2023년), SARS, 변종, 신약개발, 치료기술, 치료제, [키워드] binding binding site Chemical chemotypes Comprehensive Consensus COVID19-NMR development drug drug design Drug discovery fragment fragment screening functional identify International Intervention Ligand NMR NMR spectroscopy novel performed predict protease Protein Proteins proteome protocol provide public health RNA genome SARS-CoV-2 SARS-CoV-2. Screening Space the SARS-CoV-2 Vaccines variant variants of concern was used [DOI] 10.1002/anie.202205858 PMC 바로가기
The human host response to monkeypox infection: a proteomic case series studyArticle Published on 2022-11-082022-11-16 Journal: EMBO Molecular Medicine [Category] 유전자 메커니즘, [키워드] acute phase response Applying Biomarker case sery CFHR1 complement correlation COVID-19 disease severity Diseases endemic area healthy controls Host host response human host Infection Monkeypox virus outbreak overlap Patient plasma plasma protein Protein Proteins proteome proteomic proteomics provided Research similarities suggested suppressed the disease viral infection Viral infection. [DOI] 10.15252/emmm.202216643 PMC 바로가기
Microvascular and proteomic signatures overlap in COVID-19 and bacterial sepsis: the MICROCODE studyArticle Published on 2022-11-012022-11-15 Journal: Angiogenesis [Category] 바이오마커, 유전자 메커니즘, [키워드] 28-day mortality adult COVID-19 patients Analysis Bacterial Bacterial sepsis Biomarker clinical outcomes Clinical severity Cluster Cohort conditions coronavirus disease Correlation analysis COVID-19 COVID-19 patient dimension disease disease entity dysfunction endothelial Endothelial dysfunction explained Health healthy control high mortality Hospitalized hospitals host response impairment independent intubation marker Microcirculation Microscopy Microvascular dysfunction microvascular injury outcome analysis outcomes overlap patients plasma plasma protein predict predictor Protein proteome proteomic Proteomic signature proteomics quantified sepsis. Variation was performed was used were measured were used [DOI] 10.1007/s10456-022-09843-8 PMC 바로가기
Cellular interferon-gamma and interleukin-2 responses to SARS-CoV-2 structural proteins are broader and higher in those vaccinated after SARS-CoV-2 infection compared to vaccinees without prior SARS-CoV-2 infectionArticle Published on 2022-10-172022-11-15 Journal: PLoS ONE [Category] COVID19(2023년), SARS, 진단, [키워드] assays BNT162b2 BNT162b2 vaccine class correlated demonstrated develop dose doses epitope exhibited Frequency greater healthcare worker healthy IFN-γ IgG response IL-2 IL2 Immunity individual infected with SARS-CoV-2 Infection Interferon-gamma interleukin-2 magnitude Moderna mRNA-1273 vaccine mononuclear cell mRNA-1273 N and M nine participant Participants PCR testing peptide Peripheral blood Pfizer-BioNTech positive Post-infection Proteins proteome repeated responders response responses against robust S glycoprotein S1 and S2 S2 subunit SARS-CoV-2 SARS-COV-2 infection structural protein subunit subunits T cell response T-cell Response the SARS-CoV-2 uninfected vaccination vaccinee was determined were expressed with COVID-19 [DOI] 10.1371/journal.pone.0276241 PMC 바로가기
Changes in the urinary proteome before and after quadrivalent influenza vaccine and COVID-19 vaccinationArticle Published on 2022-10-072023-07-10 Journal: Frontiers in Immunology [Category] COVID19(2023년), [키워드] COVID–19 proteome QIV Urine vaccination. [DOI] 10.3389/fimmu.2022.946791 PMC 바로가기
Catching the Wave: Detecting Strain-Specific SARS-CoV-2 Peptides in Clinical Samples Collected during Infection Waves from Diverse Geographical LocationsArticle Published on 2022-10-072022-11-15 Journal: Viruses [Category] COVID19(2023년), SARS, 변종, 진단, 치료기술, [키워드] acute respiratory syndrome Analysis antigen detection bioinformatics caused changes in clinical Clinical data clinical samples collected coronavirus Coronavirus disease 2019 COVID-19 demonstrated detect diagnostics flexible Health help Infection location mass-spectrometry pandemic PCR peptide proteome resulting Sample SARS-CoV-2 sequence strain strain-specific Strains utility Vaccine development variant variant detection. Viral protein viral variant Wave [DOI] 10.3390/v14102205 PMC 바로가기
Noninvasive nasopharyngeal proteomics of COVID-19 patient identify abnormalities related to complement and coagulation cascade and mucosal immune systemArticle Published on 2022-09-122022-11-15 Journal: PLoS ONE [Category] SARS, 유전자 메커니즘, 치료기술, 치료제, [키워드] abnormal immune response abnormality Analysis approach Biomarker can be used cells Coagulation coagulation cascade collected combating complement COVID-19 COVID-19 patient Critical demonstrated disease down-regulated down-regulation evaluate group host response identify identity IgG4 indicate KEGG lipids marker mucosal mucosal immune nasal nasopharyngeal Nasopharyngeal swab noninvasive Pathway analysis Patient patients plasma positive Protein proteome proteomics Result SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 viral infection significantly targets thrombotic up-regulated [DOI] 10.1371/journal.pone.0274228 PMC 바로가기
Proteomic Analysis Identifies Molecular Players and Biological Processes Specific to SARS-CoV-2 Exposure in Endothelial CellsArticle Published on 2022-09-092022-11-16 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, [키워드] Activation acute respiratory disease acute respiratory syndrome addition Analysis analyzed assays Biological Blood coagulation caused cell receptor cells cellular receptors changes in clinical manifestation coronavirus coronavirus disease correlated COVID-19 cytopathic effects damage different time points disease endothelial Endothelial cell endothelial cells Endothelial dysfunction Endothelium exposure expression help HUVECs identify immune response increase in Infection lack mass spectrometry Mild symptom molecular molecular mechanism oxidative stress pandemic pathway Protein proteome proteomic proteomics proteomics. responsible SARS-CoV-2 SARS-CoV-2 entry severe cases severe respiratory failure Specific SUMO2 thrombosis triggered umbilical Vascular [DOI] 10.3390/ijms231810452 PMC 바로가기
Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactionsArticle Published on 2022-09-082022-11-16 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] accompanied Activation animal model bioinformatics cells characterized chemokine COVID-19 COVID-19 patients E protein expression Extracellular matrix immune immune response immunological immunomodulatory property Inflammation Interaction intrinsic kinases lipid metabolism Loss of Smell machine metabolic molecular multifunctional olfactory Protein proteome proteomic proteomics receptor reveal SARS-CoV-2 secretion Signaling Smell structural protein survival Symptom TGF-beta signaling the SARS-CoV-2 These data trajectory transcriptomics transcriptomics. tyrosine virion widespread [DOI] 10.3389/fimmu.2022.866564 PMC 바로가기
Serum Proteome Signatures of Anti-SARS-CoV-2 Vaccinated Healthcare Workers in Greece Associated with Their Prior Infection StatusArticle Published on 2022-09-052022-11-15 Journal: International Journal of Molecular Sciences [Category] SARS, 유전자 메커니즘, 진단, [키워드] affected All participant analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 vaccination approach bioinformatics blood sample BNT162b2 mRNA Characteristics collected contribute contributed controls Course COVID-19 COVID-19 vaccination COVID-19 vaccine database differentially expressed down-regulated Gene ontology Greece humoral immune response identify IgG immune response Immune status individuals infected patient KEGG knowledge Kyoto LC-MS/MS majority mechanism molecular over pandemic pathogenic pathway Pfizer/BioNTech processed profiling analysis Protein proteome proteomics provided Quantitative RBD-specific IgG recipients Research SARS-CoV-2 SARS-COV-2 infection sera serum signature significantly status the SARS-CoV-2 Thessaloniki titer vaccinated individual vaccination vaccination. Vaccine virus worker [DOI] 10.3390/ijms231710153 PMC 바로가기